The biggest concern heath wise of Ketamine is Kidney damage. Me being one of the biggest Dissociative heads on the Road is having to deal with kidney stones that is caused maybe half the time by Dissociatives and the other times refined sugars and such. It's quite easy to to realize it damages your kidneys because after a night dreaming with kitty you can feel it in your kidneys. You don't have to take my word for it, it is well documented in medical journals. MXE is was suppose to me an improvement on on the kidney damage issue because the guy that developed MXE for Phantom Limb Syndrome needed an alternative to Ketamine and it's damaging effects. nomad